New Evidence of Rate Limiting Proton Transfer in an SNAr Aminolysis in Acetonitrile under Synthetically Relevant ConditionsĪn early synthetic step in the synthesis of adavosertib, AZD1775, is the SNAr reaction between 4-fluoronitrobenzene and 1-methylpiperazine in acetonitrile. Manufacturing API and pharmaceutical intermediates requires the development of scalable, safe, and environmentally friendly processes. New Continuous Multiphase Flow Nitration and Cryogenic Flow Formylation: Enabling Process Development and Manufacturing of Pharmaceutical Intermediates Characterization of reactor overall mass transport performance is key to the successful transfer of reactions across scales or between plants.
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Gas–liquid reactions (such as aqueous phase hydrogenations) are frequently mass transport limited. New Step Up: Gas–Liquid Mass-Transfer Characterization at Plant Scale Using the Pressure Step Method Links to abstracts of presentations featuring use of Dynochem or Reaction Lab by AbbVie, BMS, Hovione, Lilly, Merck, Sarafinas Process & Mixing Consulting. New Selected highlights at AIChE Annual Meeting 2021 The development of a regio- and stereoselective deoxyfluorination process for the manufacture of belzutifan (MK-6482) was challenging because of a combination of particular reaction and engineering sensitivities.
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New Manufacturing Process Development for Belzutifan, Part 6: Ensuring Scalability for a Deoxyfluorination Reaction
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New Manufacturing Process Development for Belzutifan, Part 4: Nitrogen Flow Criticality for Transfer Hydrogenation ControlĪ scalable and efficient synthesis of hydroxyindanone, a key intermediate for belzutifan (MK-6482), is described. New Development of a High-Throughput Kinetics Protocol and Application to an Aza-Michael ReactionĪ case study is presented with a transition metal salt/TMSCl-catalyzed aza-Michael reaction to showcase the performance and robustness of the high-throughput kinetic platform.